Title:
【発明の名称】新規ビタミンD類似体
Document Type and Number:
Japanese Patent JPH08501572
Kind Code:
A
Abstract:
PCT No. PCT/DK93/00311 Sec. 371 Date Jan. 3, 1995 Sec. 102(e) Date Jan. 3, 1995 PCT Filed Sep. 27, 1993 PCT Pub. No. WO94/07842 PCT Pub. Date Apr. 14, 1994Compounds of formula I wherein Q is a -CH2-, -CH=CH- or -C=C-; U is a C1-C6 alkylene; R1 is hydrogen, a C1-C4 alkyl or YR' in which Y stands for the radicals -SO- or -SO2- and R' stands for a C1-C4 alkyl; R2 and R3 are independently hydrogen or C1-C4 alkyl, and additionally R2 and R3, when taken together with the starred carbon atom, may form a C3-C6 carbocyclic ring; Z is hydrogen or hydroxy; and derivatives thereof. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells. The compounds are prepared by adding an anion R- to 1(S),1(R)-bis-(tert-butyldimethylsilyl-oxy)-9,10-secopregna-5(E),7(E),10(19)-triene-20-one and the resulting compound is alkylated or acylated with R1X1 where X1 is a leaving group followed by triplet-sensitized photoisomerization and deprotection to give the compound of formula I.
Inventors:
Hansen, Kai
Brettin, Claus Ohe Svensgow
Brettin, Claus Ohe Svensgow
Application Number:
JP50859794A
Publication Date:
February 20, 1996
Filing Date:
September 27, 1993
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited A/S
International Classes:
A61K31/593; A61P3/08; A61K31/59; A61P9/12; A61P11/00; A61P17/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C401/00; (IPC1-7): C07C401/00; A61K31/59
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)