Title:
【発明の名称】新規な三環性オキシムエーテル、それらの製造方法及びそれらを含む医薬組成物
Document Type and Number:
Japanese Patent JP2937837
Kind Code:
B2
Abstract:
Ethers of tricyclic oximes of formula (I), their cis and trans isomers, enantiomers and diastereomers, and their hydrates and/or acid or base addn. salts, are new. R1 = H, alkyl, alkenyl, cycloalkyl, cycloalkyl(1-4C)alkyl, hydroxy, alkoxy, opt. substd. phenyl, opt. substd. phenyl(1-4C)alkyl, opt. substd. phenoxy, or opt. substd. phenyl(1-4C)alkoxy; or R1+R2 form a chain (i) such that a 5-8 atom ring is formed; R2, R3 = H, alkyl, alkenyl, cycloalkyl, opt. substd. indanyl, cycloalkyl(1-4C)alkyl, opt. substd. phenyl, or opt. substd. phenyl(1-4C)alkyl; or NR2R3 = a heterocyclic gp. (ii) or (iii); m = 0-4; n = 0, 1 or 2; Y' = O, S or N-R4; R4 = H, alkyl or opt. substd. (CH2)qphenyl; q, x, y = 0-4; A = a gp. (a), (b) or (c); R5, R6 = H, OH, alkyl, alkoxy, halo, CF3, alkoxycarbonyl, opt. substd. (CH2)p-phenyl or opt. substd. O-(CH2)p'-phenyl; p, p' = 0-4; unless otherwise stated, alkyl, alkoxy = 1-6C; alkenyl = 2-6C; cycloalkyl = 3-8C; opt. substd. = opt. substd. on phenyl by one or more alkyl, alkoxy, OH, halo, CF3, nitrile or nitro.
Inventors:
SHIRUAN ROORUTO
MATSUKUSU ROTSUBA
JANNSHARURU RANSURO
ERUE PURYUNIE
PIEERU RENAARU
BURUNO FUEIFUAA
BEATORISU GUADEIORAARUMETORU
MARI KUREERU RUTORI
MATSUKUSU ROTSUBA
JANNSHARURU RANSURO
ERUE PURYUNIE
PIEERU RENAARU
BURUNO FUEIFUAA
BEATORISU GUADEIORAARUMETORU
MARI KUREERU RUTORI
Application Number:
JP33334795A
Publication Date:
August 23, 1999
Filing Date:
December 21, 1995
Export Citation:
Assignee:
ADEIIRU
International Classes:
A61K31/00; A61K31/40; A61K31/407; A61K31/445; A61K31/535; A61P1/00; A61P1/08; A61P1/14; A61P25/00; A61P25/04; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/26; A61P25/28; A61P25/30; A61P25/32; A61P43/00; C07D487/04; C07D495/14; (IPC1-7): C07D495/14; A61K31/00; A61K31/40; A61K31/445; A61K31/535; C07D487/04
Attorney, Agent or Firm:
Hajime Tsukuni (2 outside)