Title:
【発明の名称】ヌクレオシド誘導体
Document Type and Number:
Japanese Patent JPH06501261
Kind Code:
A
Abstract:
PCT No. PCT/SE91/00653 Sec. 371 Date May 20, 1993 Sec. 102(e) Date May 30, 1993 PCT Filed Sep. 27, 1991 PCT Pub. No. WO92/06102 PCT Pub. Date Apr. 16, 1992.Compounds of formulae or wherein X is O; R1 is OH, phosphate, diphosphate, triphosphate or (CH2)n-O-CH2-O-P(=O)(OH)2 wherein n is 0-2; R2 is H and R3 is CH3, CH2OH, CH2-O-CH3, CH2SH, CH2F or CH2N3; or R3 is H and R2 is CH3, CH2OH, CH2-O-CH3, CH2SH, CH2F or CH2N3; and Z is Cl, Br, I, acyloxy or alkoxy; are synthesized from acyclic intermediates and are subsequently useful in the preparation of nucleoside analogues with antiviral activity against retroviruses such as HIV and hepatitis B.
Inventors:
Klason, Bjorn Olov
Samuel Elson, Bengt Vertail
Quve Aunt Stryom, Ingemal Souven-Anders
Svuan Son, Lars Iyoran
Sveenson, Stephane Carl Torre
Samuel Elson, Bengt Vertail
Quve Aunt Stryom, Ingemal Souven-Anders
Svuan Son, Lars Iyoran
Sveenson, Stephane Carl Torre
Application Number:
JP51612791A
Publication Date:
February 10, 1994
Filing Date:
September 27, 1991
Export Citation:
Assignee:
Medivil Actie Borrag
International Classes:
A61K31/505; A61K31/52; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P31/12; A61P33/10; C07D239/46; C07D405/04; C07D473/00; C07D473/02; C07F9/6512; C07F9/6558; C07F9/6561; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20; (IPC1-7): C07H19/06; A61K31/505; A61K31/52; A61K31/70; C07D239/46; C07D473/02; C07H19/16
Attorney, Agent or Firm:
Chika Takagi (2 outside)