NEW MATERIAL:Carboxymethyldithiocarbamic acid benzyl ester of formula.
USE: Useful as a raw material for the preparation of 5-mercaptotetrazolyl-1-acetic acid. It can be prepared economically, in high yield by simple process.
PROCESS: An alkali metal salt of glycine obtained by the alkali neutralization of glycine in an aqueous system, is added with a surface active agent (preferably, Nissan Disfoam CK-140, product of Nippon Yushi Co.) and/or a phase-transfer catalyst (preferably TOMAC, product of Koei Kagaku Kogyo Co.). CS2 is added dropwise to the mixture at 0W50°C, preferably 25W35°C to obtain M(1)OOCCH2 NHCS2M(1) [M(1) is alkali metal]. The product is added with benzyl halide and neutralized with a mineral acid to about 2.5pH to obtain the objective compound of formula.
OONISHI AKIHISA
INOUE HIROO
| JPS57174142A | 1982-10-26 |