Title:
【発明の名称】浸透圧制御放出薬剤送達装置
Document Type and Number:
Japanese Patent JP2003513033
Kind Code:
A
Abstract:
The present invention is related to a pH insensitive drug delivery device, specifically an osmotic pump, for the controlled release of a beneficial agent in an environment of use, which comprises (a) a core prepared from an admixture comprising: (i) a therapeutically effective amount of at least one beneficial agent, or salts thereof, that has a solubility profile that is dependent on the pH level of the environment of use; and (ii) at least one pH modulating agent; and (b) a controlled porosity, microporous coating which surrounds the core. In a second embodiment, the invention is also related to a pH insensitive, osmotic drug delivery device for the controlled release of a beneficial agent in an environment of use, which comprises (a) a core containing a therapeutically effective amount of at least one beneficial agent, or salts thereof, that has a solubility profile that is dependent on the pH level of the environment of use; and b) a controlled porosity, microporous coating which surrounds the core and has at least one aperture.
Inventors:
Ladie, Stephen Bee
Deville, Laura A
Story, David E
Deville, Laura A
Story, David E
Application Number:
JP2001534354A
Publication Date:
April 08, 2003
Filing Date:
October 27, 2000
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61D7/00; A61K9/00; A61K9/22; A61K9/32; A61K9/36; A61K31/00; A61K31/337; A61K31/496; A61K45/00; A61K47/12; A61N5/10; A61P35/00; A61P43/00; (IPC1-7): A61K9/00; A61D7/00; A61K31/337; A61K31/496; A61K45/00; A61K47/12; A61N5/10; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)