Title:
【発明の名称】酸化型アポリポタンパク質およびその使用方法
Document Type and Number:
Japanese Patent JP2003514918
Kind Code:
A
Abstract:
The present invention relates to oxidized forms of apolipoproteins and methods of use in diagnosis and treatment of diseases associated with oxidative stress, such as cardiovascular diseases, in particular of atherosclerosis. Specifically, oxidized forms of ApoA-1 and ApoA-II having specific methionine residues oxidized are provided. Methods of use include increasing effux and alpha -TOH, lowering lipid concentrations and preventing or treating lipid-associated conditions are provided. Methods of detecting oxidative stress, genotypes and extent of lipid associated conditions are also provided by utilizing the oxidative apolipoproteins.
Inventors:
Stocker, roland
One, Shin Li
Wilken, David
One, Shin Li
Wilken, David
Application Number:
JP2001540158A
Publication Date:
April 22, 2003
Filing Date:
November 27, 2000
Export Citation:
Assignee:
The Heart Research Institute Limited
International Classes:
A61K38/17; A61P9/06; A61P9/10; C07K14/47; C07K14/775; C12Q1/68; A61K38/00; (IPC1-7): C07K14/47; A61K38/17; A61P9/06; A61P9/10; C07K14/775; C12Q1/68
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)