Title:
【発明の名称】ホスホリパーゼA▲下2▼の阻害剤
Document Type and Number:
Japanese Patent JPH11507644
Kind Code:
A
Abstract:
The invention relates to method for identifying prostatic intraepithelial neoplasia, methods for determining metastatic potential of tumors, and to methods and compositions for inhibiting or preventing metastasis of cancers. In one aspect, the invention provides a method to determine metastatic potential of tumors, particularly prostatic tumors. In another aspect, the invention provides a method of identifying prostate cancer associated conditions, particularly prostatic intraepithelial neoplasia. In these regards, the invention relate to determining protein or mRNA of effectors of arachidonic acid release, particularly uteroglobin protein or mRNA, to identify intermediate conditions such as PIN or to gauge metastatic potential of prostatic tumors.The invention also relates to methods and compositions that prevent or inhibit metastasis of cancers. In this regard, the invention particularly relates to methods and compositions that inhibit arachidonic acid, those that inhibit phospholipase A2. More particularly in this regard, the invention relates to uteroglobin or muteins, peptide analogs or mimetics of uteroglobin and lipocortins or muteins, peptide analogs, or mimetics of lipocortins that inhibit metastasis. Especially it relates to methods and compositions in which uteroglobins, particularly human uteroglobins, inhibit or prevent metastasis of cancer, particularly prostatic cancer.
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Inventors:
Stephen Earl Pachierno
Michael jay maniac
Michael jay maniac
Application Number:
JP50224697A
Publication Date:
July 06, 1999
Filing Date:
June 06, 1996
Export Citation:
Assignee:
The George Washington University
International Classes:
C12Q1/02; A61K31/405; A61K31/435; A61K31/473; A61K38/00; A61K38/17; A61K45/00; A61P35/00; C07K14/47; C12N5/08; C12Q1/68; G01N33/50; G01N33/574; (IPC1-7): A61K45/00; A61K31/405; A61K31/435; A61K38/00; C12Q1/02; C12Q1/68
Attorney, Agent or Firm:
Ichinose Miyao