Title:
【発明の名称】ホスホン酸基本カチオン性脂質
Document Type and Number:
Japanese Patent JPH11507815
Kind Code:
A
Abstract:
The present invention provides novel phosphonic acid-based cationic lipids of the general structure:or a salt, or solvate, or enantiomers thereof wherein; (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) R3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X- is an anion or polyanion; (f) Y is N or 0, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid.The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
Inventors:
Dwyer, brian patrick
Lebedef, Alexander Buoy
Brown, bob dale
Schwartz, David Aaron
Lebedef, Alexander Buoy
Brown, bob dale
Schwartz, David Aaron
Application Number:
JP50178897A
Publication Date:
July 13, 1999
Filing Date:
June 05, 1996
Export Citation:
Assignee:
Jinta Incorporated
International Classes:
C12N15/09; A61K9/127; A61K31/66; A61K31/70; A61K45/06; A61K47/24; A61K47/28; A61K47/48; A61K48/00; C07F9/40; C07J9/00; C07J41/00; C07J43/00; C07J51/00; (IPC1-7): C12N15/09; A61K31/70; A61K47/28; A61K48/00; C07J9/00; C07J41/00; C07J43/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)