Title:
【発明の名称】ポリケチドとその合成
Document Type and Number:
Japanese Patent JP2002519014
Kind Code:
A
Abstract:
A polyketide synthase ("PKS") of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.
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Inventors:
Reed Ray, Peter Francis
Staunton, James
Cortez, Jesus
MacArthur, Hamish Alastair Irvine
Staunton, James
Cortez, Jesus
MacArthur, Hamish Alastair Irvine
Application Number:
JP2000557261A
Publication Date:
July 02, 2002
Filing Date:
June 29, 1999
Export Citation:
Assignee:
Biotika Technology Limited
Pfizer Inc.
Pfizer Inc.
International Classes:
A01K67/027; A61K31/7042; A61K31/7048; A61P31/04; C07H17/08; C07K19/00; C12N5/10; C12N9/10; C12N11/18; C12N15/00; A01H5/00; C12N15/09; C12N15/52; C12P17/06; C12P17/08; C12P19/62; (IPC1-7): C12N15/09; A01H5/00; A01K67/027; C07H17/08; C12N5/10; C12N11/18; C12P17/08
Domestic Patent References:
| JPH05504890A | 1993-07-29 | |||
| JPH09505983A | 1997-06-17 |
Foreign References:
| WO1998001571A2 | 1998-01-15 | |||
| WO1998001571A2 | 1998-01-15 |
Other References:
JPN6009031154; Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．， ｖｏｌ．１１９， ｐｐ．１０５５３-１０５５４ （１９９７）
JPN6013000788; Ｇｅｎｅ Ｖｏｌ．１８３, 1996, ｐ．２３１-２３６
JPN6009031154; Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．， ｖｏｌ．１１９， ｐｐ．１０５５３-１０５５４ （１９９７）
JPN6013000788; Ｇｅｎｅ Ｖｏｌ．１８３, 1996, ｐ．２３１-２３６
JPN6009031154; Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．， ｖｏｌ．１１９， ｐｐ．１０５５３-１０５５４ （１９９７）
Attorney, Agent or Firm:
Takashi Ishida (4 others)