Title:
【発明の名称】ヘモグロビンおよびその類似体の細菌および酵母での生成
Document Type and Number:
Japanese Patent JP3013902
Kind Code:
B2
Abstract:
A method of producing a hemoglobin-like protein wherein an alpha globin-like polypeptide and a beta globin-like polypeptide are each expressed in transformed non-erythrocyte cells such as bacterial or yeast cells, the method comprising expressing the alpha and beta globin-like polypeptide in the same cell in such manner that the alpha and beta globin-like polypeptides are assembled and combined with heme so as to intracellularly produce a biologically functional hemoglobin-like protein in soluble, recoverable form.
Inventors:
Hoffman, Stephen Jay.
Rooker, Douglas El.
Rosendhal, Mary S.
Stettler, Gary Elle.
Wagenbach, Mitchell
Rooker, Douglas El.
Rosendhal, Mary S.
Stettler, Gary Elle.
Wagenbach, Mitchell
Application Number:
JP50822090A
Publication Date:
February 28, 2000
Filing Date:
May 10, 1990
Export Citation:
Assignee:
Somatogen, Inc.
International Classes:
A61K47/48; C07K14/00; C07K14/805; C12N15/09; C12N15/12; C12N15/81; C07K19/00; C12P21/02; G01N33/53; A61K38/00; C12R1/19; C12R1/865; (IPC1-7): C12N15/09; C07K14/805; C12P21/02
Attorney, Agent or Firm:
Koji Kobayashi