Title:
【発明の名称】増殖分化因子-11
Document Type and Number:
Japanese Patent JP2002526034
Kind Code:
A
Abstract:
A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.
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Inventors:
Lee, Se-jin
McFarlon, Alexandra, Sea.
McFarlon, Alexandra, Sea.
Application Number:
JP2000562498A
Publication Date:
August 20, 2002
Filing Date:
July 28, 1999
Export Citation:
Assignee:
The Johns Hopkins University School of Medicine
International Classes:
A01K67/027; A23L13/00; A61K31/7088; A61K39/395; A61K45/00; A61K48/00; A61P13/12; A61P19/00; A61P21/00; C07K14/475; C12N15/09; C12N15/85; (IPC1-7): A01K67/027; A61K31/7088; A61K39/395; A61K45/00; A61K48/00; A61P13/12; A61P19/00; A61P21/00; C12N15/09
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)