Title:
【発明の名称】プロテインチロシンキナーゼ及びそのリガンド
Document Type and Number:
Japanese Patent JPH09503381
Kind Code:
A
Abstract:
PCT No. PCT/GB94/01479 Sec. 371 Date Jun. 10, 1996 Sec. 102(e) Date Jun. 10, 1996 PCT Filed Jul. 8, 1994 PCT Pub. No. WO95/02057 PCT Pub. Date Jan. 19, 1995The invention relates to a novel tyrosine kinase designated brk and the use of this tyrosine kinase in the development of diagnostic and therapeutic approaches to cancer. The novel tyrosine kinase was isolated from a human metastatic breast tumor using a PCR based differential screening approach and has the deduced amino acid sequence shown in SEQ ID NO:2.
Inventors:
Gusterson, Barry Austin
Crompton, Mark Roger
Mitchell, Philip John
Barker, Karen Tracy
Kamalati, Tahele
Paige, Martin John
Spence Paul
Crompton, Mark Roger
Mitchell, Philip John
Barker, Karen Tracy
Kamalati, Tahele
Paige, Martin John
Spence Paul
Application Number:
JP50392295A
Publication Date:
April 08, 1997
Filing Date:
July 08, 1994
Export Citation:
Assignee:
The Institute of Cancer Research
The Welcome Foundation Limited
The Welcome Foundation Limited
International Classes:
A61K31/275; A61K31/35; A61K31/55; A61K31/70; A61K38/00; A61K39/395; A61K45/00; A61K47/48; A61K48/00; A61P35/00; C07H21/04; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/12; C12N15/54; C12Q1/48; C12Q1/68; G01N33/573; C12R1/91; (IPC1-7): C12N15/09; A61K31/70; A61K38/00; A61K39/395; A61K45/00; A61K48/00; C07H21/04; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12Q1/48; C12Q1/68; G01N33/573
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)