Title:
【発明の名称】ピロリジニルヒドロキサム酸化合物及びその製造方法
Document Type and Number:
Japanese Patent JP3035356
Kind Code:
B2
Abstract:
A compound of the formula: and it pharmaceutically acceptable salt, wherein A is hydrogen, hydroxy or OY, where Y is a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, CF3, C1-C4 alkyloxy, and carboxy-C1-C4 alkyloxy; X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiopheny, 1-tetralone-6-yl, C1-C4 alkylenedioxy, pyridyl, furyl and thienyl, these groups optionally being substituted with up to three substituents selected from halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, NO2, CF3 and SO2CH3; and R is hydrogen, C1-C4 alkyl or a hydroxy protecting group. These compounds and pharmaceutical compositions containing them are useful as analgesic, antiinflammatory, diuretic, anesthetic or neuroprotective agents, or an agent for stroke or treatment of functional bowel diseases such as abdominal pain, for the treatment of a mammalian subject, especially a human subject. Further, the present invention provides processes for producing the hydroxamic compounds of formula (I) and their intermediate compounds of formula (II).
Inventors:
Fumitaka Ito
Application Number:
JP52917496A
Publication Date:
April 24, 2000
Filing Date:
March 28, 1996
Export Citation:
Assignee:
Pfizer Pharmaceuticals Co., Ltd.
International Classes:
A61K31/40; A61K31/4025; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61P1/00; A61P7/00; A61P7/10; A61P23/00; A61P25/00; A61P25/04; A61P25/28; A61P29/00; A61P43/00; C07D295/12; C07D207/12; C07D213/54; C07D295/13; C07D307/79; C07D401/06; C07D401/12; C07D405/06; C07D405/12; C07D405/14; C07D409/12; C07D; (IPC1-7): C07D207/12; A61K31/40; A61K31/44; A61P1/00; A61P7/00; A61P23/00; A61P25/04; A61P25/28; A61P29/00; A61P43/00; C07D295/12; C07D401/12; C07D405/12; C07D405/14; C07D409/12
Other References:
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，Ｖｏｌ．３７，Ｎｏ．２６，ｐ．４４９０−４４９８（１９９４）
Attorney, Agent or Firm:
Hiroshi Kobayashi