Title:
【発明の名称】オンコスタチンMおよび白血病阻害因子の受容体
Document Type and Number:
Japanese Patent JPH07501941
Kind Code:
A
Abstract:
A receptor protein comprising a gp130 polypeptide linked to a single-chain leukemia inhibitory factor receptor (LIF-R) polypeptide is capable of binding both oncostatin M and leukemia inhibitory factor (LIF). The receptor protein binds LIF with greater affinity than does the single-chain LIF-R polypeptide alone. The receptor may be produced as a fusion protein in recombinant cells. The gp130 polypeptide binds oncostatin M, but with lower affinity than does the inventive receptor protein.
Inventors:
Gearing, david pee
Application Number:
JP50958593A
Publication Date:
March 02, 1995
Filing Date:
November 20, 1992
Export Citation:
Assignee:
IMMUNEX CORPORATION
International Classes:
C12N15/09; A61K47/48; C07K14/47; C07K14/705; C07K14/71; C07K14/715; C07K16/00; C07K19/00; C12P21/02; A61K38/00; C12R1/91; (IPC1-7): C12P21/02; A61K47/48; C07K14/47; C12N5/10; C12N15/12; C12N15/62
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)