Title:
【発明の名称】組み換えウイルス免疫治療
Document Type and Number:
Japanese Patent JPH09503902
Kind Code:
A
Abstract:
Attenuated vaccinia or canarypox recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFN gamma ; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
Inventors:
Paoletti, Enzo
Tartagria, james
Cox, william eye
Tartagria, james
Cox, william eye
Application Number:
JP51728194A
Publication Date:
April 22, 1997
Filing Date:
January 21, 1994
Export Citation:
Assignee:
Virogenetics Corporation
International Classes:
C12N15/09; A61K35/76; A61K38/00; A61K38/16; A61K38/17; A61K38/21; A61K39/00; A61K39/12; A61K39/145; A61K39/17; A61K39/205; A61K39/275; A61K39/285; A61K48/00; A61P35/00; A61P37/04; C07H21/04; C07K14/015; C07K14/02; C07K14/03; C07K14/035; C07K14/045; C07K14/05; C07K14/06; C07K14/065; C07K14/07; C07K14/11; C07K14/12; C07K14/125; C07K14/145; C07K14/15; C07K14/155; C07K14/16; C07K14/165; C07K14/175; C07K14/18; C07K14/33; C07K14/47; C07K14/52; C07K14/525; C07K14/535; C07K14/54; C07K14/55; C07K14/57; C07K14/705; C07K14/82; C12N7/00; C12N15/00; C12N15/19; C12N15/86; C12N15/863; C12P21/04; (IPC1-7): C12N7/00; A61K35/76; A61K38/00; A61K38/16; A61K38/17; A61K38/21; A61K39/00; A61K48/00; C07H21/04; C07K14/52; C07K14/82; C12N15/09
Attorney, Agent or Firm:
Seiji Yanagida (1 person outside)