Title:
【発明の名称】エストリオ-ルユウドウタイノ セイゾウホウ
Document Type and Number:
Japanese Patent JPS5842199
Kind Code:
B2
Abstract:
1452794 Estriol nicotinates THERAMEX SA 26 Feb 1975 [26 Feb 1974] 8712/74 Heading C2U The invention comprises compounds of formula (wherein R is nicotinoyl or its N-oxide; and R1 is C 3-7 aliphatic organic acyl; aromatic, alicyclic or heterocyclic organic acyl; or Me, Et, Pr, allyl, methallyl, cyclopentyl or dialkylaminoalkyl); and their preparation from estriol or its 3-ethers by esterification with nicotinoyl chloride or its N-oxide; or from estriol 16,17- dinicotinate or its N,N1 -dioxide by esterification with an appropriate acylating agent. The nicotinoyl groups may be N-oxidized by reaction with per-acids. Estriol 16,17-dinicotinate is prepared by selective hydrolysis of the trinicotinate. Compounds I are credited with hypolipidaemic and anti-arteriosclerotic activity, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, rectal and nasal (aerosol) administration.
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Inventors:
NIKORASU GUERITE
Application Number:
JP2445275A
Publication Date:
September 17, 1983
Filing Date:
February 26, 1975
Export Citation:
Assignee:
TERAMETSUKUSU SA
International Classes:
A61K31/565; A61P3/06; C07J43/00; (IPC1-7): C07J43/00
Attorney, Agent or Firm:
Akaoka Mio