Title:
【発明の名称】SRCキナーゼ阻害剤化合物
Document Type and Number:
Japanese Patent JP2003523942
Kind Code:
A
Abstract:
Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.
Inventors:
Armstrong, Helen M
Beresis, lithyard
Gure, Ji Yun El
Holmes, Mark A
Hong, Singhuang
Mills, Thunder Gi
Parsons, William H
Sinclair, Peter Theei
Steiner, Mark Gi
Won, Frederik
Zara, Dennis M
Beresis, lithyard
Gure, Ji Yun El
Holmes, Mark A
Hong, Singhuang
Mills, Thunder Gi
Parsons, William H
Sinclair, Peter Theei
Steiner, Mark Gi
Won, Frederik
Zara, Dennis M
Application Number:
JP2001505922A
Publication Date:
August 12, 2003
Filing Date:
June 26, 2000
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/506; A61K31/519; A61K31/52; A61K31/5377; A61K45/00; A61P1/00; A61P17/06; A61P19/02; A61P29/00; A61P37/00; A61P43/00; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D491/048; C07D491/056; C07F5/02; C07F9/6512; C07D473/32; (IPC1-7): C07D401/14; A61K31/506; A61K31/519; A61K31/52; A61K31/5377; A61K45/00; A61P1/00; A61P17/06; A61P19/02; A61P29/00; A61P37/00; A61P43/00; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D473/32; C07D487/04; C07D491/048; C07D491/056; C07F5/02; C07F9/6512
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)