PURPOSE: To dispense with washing and disinfection executed whenever the device is used by inserting a reaction tube between a blood feeding-in tube and a discharge tube connected to the human body, applying various physical simulations from the tube to blood for passing through the inside of the tube, and also, injecting various kinds of medicines.

CONSTITUTION: By a motion of rollers 9, 10, Ringer's solution in a tube 14, and subsequently, blood are fed into a reaction tube 16 by a flow rate of about 200ml per minute. Also, gaseous ozone generated in an ozone generator 18 is fed into an inner cavity 17 of the reaction tube 16 through a tube 24 from a tube 23. Subsequently, by a motion of rollers 11, 12, blood in a tube 15 is returned to a patient. In this case, by vibration of the upper face of a temperature control box 2 by an ultrasonic vibrator 4, mixing of blood and ozone in the tube is quickened, disinfection and sterilization by ozone of a pathogenic organ in blood are executed, and a breakdown of a white blood corpuscle (T cell, etc.) which is weak due to a fact that pathogenic organ exists in great quantities in a cell by ultrasonic vibration is executed. Simultaneously, bacteria are sterilized surely by ultraviolet rays radiated from a lamp 7.