Title:
【発明の名称】スクリーニング・アッセイ
Document Type and Number:
Japanese Patent JPH06503713
Kind Code:
A
Abstract:
PCT No. PCT/US91/06839 Sec. 371 Date Oct. 7, 1993 Sec. 102(e) Date Oct. 7, 1993 PCT Filed Sep. 20, 1991A method for the identification of compounds as inhibitors of oncoprotein action is described. A compound is identified as an inhibitor of oncoprotein action based on its ability to modulate the transcription of a reporter gene. Transcription of the reporter gene is dependent upon the binding of a fusion oncoprotein to a specific DNA binding element positioned upstream of the reporter gene promoter. The fusion oncoprotein contains a transcriptional regulatory domain from an oncoprotein and a DNA binding domain from a different protein.
Inventors:
Brent, Roger
Application Number:
JP51607191A
Publication Date:
April 28, 1994
Filing Date:
September 20, 1991
Export Citation:
Assignee:
Brent, Roger
Goremis, Erica
Lechu, Karen Ev
Anderson, Catherine
Goremis, Erica
Lechu, Karen Ev
Anderson, Catherine
International Classes:
C12N1/19; C12N5/10; C12N15/09; C12Q1/68; G01N33/50; C12N1/00; G01N33/68; (IPC1-7): C12N15/12; C12N15/65
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)