Title:
【発明の名称】センスmRNA治療
Document Type and Number:
Japanese Patent JP2002508299
Kind Code:
A
Abstract:
The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.
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Inventors:
Woolfoot M.
Widde Holt Christine
Taylor margaret
Widde Holt Christine
Taylor margaret
Application Number:
JP2000511884A
Publication Date:
March 19, 2002
Filing Date:
September 18, 1998
Export Citation:
Assignee:
Sequator, ink.
International Classes:
C12N15/09; A61K31/712; A61K31/7125; A61K38/00; A61K38/16; A61K38/22; A61K38/45; A61K38/48; A61K48/00; A61P1/16; A61P3/00; A61P3/10; A61P7/02; A61P7/06; A61P9/02; A61P9/10; A61P11/06; A61P13/08; A61P13/12; A61P15/10; A61P17/02; A61P17/14; A61P19/02; A61P21/00; A61P21/04; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; C07H21/04; C12N15/67; C12N15/68; (IPC1-7): C07H21/04; A61K31/712; A61K31/7125; A61K48/00; A61P1/16; A61P3/00; A61P3/10; A61P7/02; A61P7/06; A61P9/02; A61P9/10; A61P11/06; A61P13/08; A61P13/12; A61P15/10; A61P17/02; A61P17/14; A61P19/02; A61P21/00; A61P21/04; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; C12N15/09
Domestic Patent References:
| JPH07500967A | 1995-02-02 |
Foreign References:
| WO1997011085A1 | 1997-03-27 | |||
| EP0726319A2 | 1996-08-14 | |||
| EP0204401A1 | 1986-12-10 |
Other References:
AURUP: "TRANSLATION OF 2'-MODIFIED MRNA IN VITRO AND IN VIVO", NUCLEIC ACIDS RESEARCH, vol. V22 , JPN5001000361, 1994, pages 4963 - 4968, ISSN: 0001325327
YOKOE H & MEYER T: "SPATIAL DYNAMICS OF GFP-TAGGED PROTEINS INVESTIGATED BY LOCAL FLUORESCENCE ENHANCEMENT", NATURE BIOTECHNOLOGY, vol. V14, JPN5001000364, 1 October 1996 (1996-10-01), pages 1252 - 1256, ISSN: 0001325328
NIELSEN D & SHAPIRO D: "PREPARATION OF CAPPED RNA TRANSCRIPTS USING T7 RNA POLYMERASE", NUCLEIC ACIDS RESEARCH, vol. V14 , JPN5001000365, 1986, pages 5936, ISSN: 0001325329
LEWIS S: "THE INFLUENCE OF 5'AND 3'END STRUCTURES ON PRE-MRNA METABOLISM", JOURNAL OF CELL SCIENCE, vol. V19 , JPN5001000367, 1995, pages 13 - 19, ISSN: 0001325330
SPROAT B S: "CHEMISTRY AND APPLICATIONS OF RIBONUCLEOSIDE 5'-0-(ALPHA-P-BORANOTRIPHOSPHATES) 以下備考", JOURNAL OF BIOTECHNOLOGY, vol. V41 N2, JPN5001000368, 31 July 1995 (1995-07-31), pages 221 - 238, ISSN: 0001325336
HE,K.: "THE SYNTHESIS OF RIBONUCLEOSIDE 5'-0-(ALPHA-P-BORANOTRIPHOSPHATES),SEPARATION OF 以下備考", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. V36 , JPN5001000369, 1997, pages 159, ISSN: 0001325337
DELAFONTAINE: "REGULATION OF VASCULAR SMOOTH MUSCLE CELL INSULINE-LIKE GROWTH FACTOR I 以下備考", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. V270 N24, JPN5001000359, 16 June 1995 (1995-06-16), pages 14383 - 14388, ISSN: 0001325331
GROSS H.: "HETEROLOGOUS EXPRESSION AS A TOOL FOR GENE IDENTIFICATION AND ANALYSIS", JOURNAL OF BIOTECHNOLOGY, vol. V41 N2, JPN5001000360, 31 July 1995 (1995-07-31), pages 91 - 110, ISSN: 0001325332
HEIDENREICH O: "CHEMICALLY MODIFIED RNA:APPROACHES AND APPLICATIONS", FASEB JOURNAL, vol. V7 N1, JPN5001000362, 1 January 1993 (1993-01-01), pages 90 - 96, ISSN: 0001325333
HEIDENREICH O: "HIGH ACTIVITY AND STABILITY OF HAMMERHEAD RIBOZYMES CONTAINING 2'-MODIFIED PYRIMIDINE 以下備考", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. V269, JPN5001000363, 21 January 1994 (1994-01-21), pages 2131 - 2138, ISSN: 0001325334
BERNSTEIN P & ROSS J: "POLY(A),POLY(A) BINDING PROTEIN AND THE REGULATION OF MRNA STABILITY", TRENDS IN BIOCHEMICAL SCIENCES, vol. V14, JPN5001000366, 1 September 1989 (1989-09-01), pages 373 - 377, ISSN: 0001325335
YOKOE H & MEYER T: "SPATIAL DYNAMICS OF GFP-TAGGED PROTEINS INVESTIGATED BY LOCAL FLUORESCENCE ENHANCEMENT", NATURE BIOTECHNOLOGY, vol. V14, JPN5001000364, 1 October 1996 (1996-10-01), pages 1252 - 1256, ISSN: 0001325328
NIELSEN D & SHAPIRO D: "PREPARATION OF CAPPED RNA TRANSCRIPTS USING T7 RNA POLYMERASE", NUCLEIC ACIDS RESEARCH, vol. V14 , JPN5001000365, 1986, pages 5936, ISSN: 0001325329
LEWIS S: "THE INFLUENCE OF 5'AND 3'END STRUCTURES ON PRE-MRNA METABOLISM", JOURNAL OF CELL SCIENCE, vol. V19 , JPN5001000367, 1995, pages 13 - 19, ISSN: 0001325330
SPROAT B S: "CHEMISTRY AND APPLICATIONS OF RIBONUCLEOSIDE 5'-0-(ALPHA-P-BORANOTRIPHOSPHATES) 以下備考", JOURNAL OF BIOTECHNOLOGY, vol. V41 N2, JPN5001000368, 31 July 1995 (1995-07-31), pages 221 - 238, ISSN: 0001325336
HE,K.: "THE SYNTHESIS OF RIBONUCLEOSIDE 5'-0-(ALPHA-P-BORANOTRIPHOSPHATES),SEPARATION OF 以下備考", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. V36 , JPN5001000369, 1997, pages 159, ISSN: 0001325337
DELAFONTAINE: "REGULATION OF VASCULAR SMOOTH MUSCLE CELL INSULINE-LIKE GROWTH FACTOR I 以下備考", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. V270 N24, JPN5001000359, 16 June 1995 (1995-06-16), pages 14383 - 14388, ISSN: 0001325331
GROSS H.: "HETEROLOGOUS EXPRESSION AS A TOOL FOR GENE IDENTIFICATION AND ANALYSIS", JOURNAL OF BIOTECHNOLOGY, vol. V41 N2, JPN5001000360, 31 July 1995 (1995-07-31), pages 91 - 110, ISSN: 0001325332
HEIDENREICH O: "CHEMICALLY MODIFIED RNA:APPROACHES AND APPLICATIONS", FASEB JOURNAL, vol. V7 N1, JPN5001000362, 1 January 1993 (1993-01-01), pages 90 - 96, ISSN: 0001325333
HEIDENREICH O: "HIGH ACTIVITY AND STABILITY OF HAMMERHEAD RIBOZYMES CONTAINING 2'-MODIFIED PYRIMIDINE 以下備考", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. V269, JPN5001000363, 21 January 1994 (1994-01-21), pages 2131 - 2138, ISSN: 0001325334
BERNSTEIN P & ROSS J: "POLY(A),POLY(A) BINDING PROTEIN AND THE REGULATION OF MRNA STABILITY", TRENDS IN BIOCHEMICAL SCIENCES, vol. V14, JPN5001000366, 1 September 1989 (1989-09-01), pages 373 - 377, ISSN: 0001325335
Attorney, Agent or Firm:
Tsutomu Kanakubo