Title:
【発明の名称】出生前診断を可能にする母体血液からの胎児細胞の分離
Document Type and Number:
Japanese Patent JP2935741
Kind Code:
B2
Abstract:
PCT No. PCT/AU89/00517 Sec. 371 Date Jul. 3, 1991 Sec. 102(e) Date Jul. 3, 1991 PCT Filed Nov. 29, 1989 PCT Pub. No. WO90/06509 PCT Pub. Date Jun. 14, 1990.This invention relates to a method for the isolation of trophoblast (placental) cells from the blood of a pregnant mammal so as to provide the essential starting material, namely cells derived from the fetus, to enable genetic and/or biochemical information about the fetus to be obtained. In particular, this invention relates to the use of monoclonal antibodies specific for membrane protein markers on mammalian trophoblasts to isolate trophoblast cells from maternal blood. These cells may then be used to obtain fetal genetic and/or biochemical information early in pregnancy. The present invention is particularly relevant for detecting human fetal abnormalities.
Inventors:
MYUURAA UTSUTSU WARUTAA
HOOZU KYASARIN SUTERA
HOOZU KYASARIN SUTERA
Application Number:
JP50010589A
Publication Date:
August 16, 1999
Filing Date:
November 29, 1989
Export Citation:
Assignee:
FURINDAAZU TEKUNOROJIIZU PTY LTD
International Classes:
A61K39/395; A61K49/00; C07K14/00; C07K14/47; C07K14/705; G01N33/53; C07K16/00; C07K16/18; C12M1/28; C12N5/07; C12N5/073; C12N5/10; C12N15/02; C12N15/09; C12P21/08; G01N33/569; G01N33/577; G01N33/68; C12R1/91; (IPC1-7): G01N33/53; C12N5/06; C12N15/02; C12N15/09; G01N33/577
Other References:
【文献】PROC.NATL.ACAD.SCI.USA,VOL.78,NO.8,(1981)P.5147~5150
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)