Title:
【発明の名称】二環式中間体を使用したヌクレオシド類似体の立体選択的合成
Document Type and Number:
Japanese Patent JP3110461
Kind Code:
B2
Abstract:
PCT No. PCT/CA94/00311 Sec. 371 Date Feb. 2, 1995 Sec. 102(e) Date Feb. 2, 1995 PCT Filed Jun. 7, 1994 PCT Pub. No. WO94/29301 PCT Pub. Date Dec. 22, 1994The present invention relates to a process for producing predominantly pure cis nucleoside analogues of formula (I), wherein X is S, or O; Y is S, CH2, O or CH(R); wherein R is azido or halogen; and R2 is a purine or pyrimidine base; via the coupling of a silylated purine or pyrimidine base in the presence of an appropriate Lewis acid with a bicyclic intermediate of formula (III) wherein Z is S or O; followed by conversion of the resulting intermediate of formula (II) to an alkyl ester and reduction to yield a compound of formula (I). (I) (II) (III)
Inventors:
Mansoa, Tarek S
Evans, Colleen A
Jin, Haorn
Sidiqui, Arshad M
Tesse, Alan H.L
Evans, Colleen A
Jin, Haorn
Sidiqui, Arshad M
Tesse, Alan H.L
Application Number:
JP50113995A
Publication Date:
November 20, 2000
Filing Date:
June 07, 1994
Export Citation:
Assignee:
Biochem Pharma Incorporated
International Classes:
A61K31/505; C07D403/04; A61P31/12; C07D411/04; C07D473/00; C07D497/08; C07D; (IPC1-7): C07D411/04
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)
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