Title:
【発明の名称】ステロイド修飾オリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH04500687
Kind Code:
A
Abstract:
An oligonucleotide conjugated to a steroid the oligonucleotide comprising: wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; B is a naturally occurring base, the steroid is bound to the oligonucleotide utilizing the naturally occurring bases through an (-oxycarbonyl-amino)-decylamine-moiety, and NUC is an oligonucleotide.
Inventors:
Letzinger Robert El
Application Number:
JP50922390A
Publication Date:
February 06, 1992
Filing Date:
June 06, 1990
Export Citation:
Assignee:
Northwestern University
International Classes:
A61K31/704; A61K31/7088; A61P31/12; A61P31/18; C07H21/00; C07J43/00; C07J51/00; (IPC1-7): A61K31/705; C07H21/00; C07J43/00
Attorney, Agent or Firm:
Minoru Nakamura (8 outside)