Title:
【発明の名称】置換尿素化合物及びそれらの製法及び使用
Document Type and Number:
Japanese Patent JPH05504358
Kind Code:
A
Abstract:
New substituted urea compounds of formula I, or a pharmaceutically acceptable salt thereof: (* CHEMICAL STRUCTURE *) I wherein A is (* CHEMICAL STRUCTURE *) wherein R3 is an oxadiazol, substituted with C1-8-alkyl, C2-8-alkenyl, C2-8 alkynyl, C3-7 cycloalkyl, benzyl, phenyl, C1-6-alkoxy, C1-6-alkylthio, amino or alkylamino; R2 is -H or lower alkyl; X is O or S; and R1 is a group of formula II, III, IV or V (* CHEMICAL STRUCTURE *) II (* CHEMICAL STRUCTURE *) III (* CHEMICAL STRUCTURE *) IV where n is 2 or 3, P is 1 or 2, q is 1 to 3, r is 1-3 and R4 and R5 are H,C1-7 alkyl or C3-6 cycloalkyl; and N-oxides thereof. The compounds are useful in pharmaceutical preparations for treating psychotic disorders, nausea and vomiting.
Inventors:
Hansen Yang Bond
Application Number:
JP50458691A
Publication Date:
July 08, 1993
Filing Date:
February 15, 1991
Export Citation:
Assignee:
Novo Nordisk Actiesel Scab
International Classes:
A61K31/46; A61K31/55; A61P43/00; C07D413/14; C07D451/04; C07D451/14; C07D453/02; C07D453/06; C07D457/04; C07D471/08; A61K31/435; C07D487/08; (IPC1-7): A61K31/435; A61K31/46; A61K31/55; C07D413/14; C07D451/14; C07D453/02; C07D453/06; C07D457/04; C07D471/08; C07D487/08
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)