Title:
【発明の名称】置換2-アリールベンズアゾール化合物及び抗腫瘍剤としてのそれらの使用
Document Type and Number:
Japanese Patent JP2003507462
Kind Code:
A
Abstract:
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, -CH2- or -CH=Ch-, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the benzene ring of the benzazole nucleus has a halogen substituent, preferably flourine, and the 2-phenyl group has a 4'-amino substituent which may be conjugated with an amino acid to provide a water soluble amino acid amide prodrug or salt thereof.
Inventors:
Stevens, Malcolm Francis Graham
Westwell, Andrew David
Chua, Mayse
Pool, Tracy Dawn
Hutchinson, Ian Paul
Westwell, Andrew David
Chua, Mayse
Pool, Tracy Dawn
Hutchinson, Ian Paul
Application Number:
JP2001518442A
Publication Date:
February 25, 2003
Filing Date:
August 21, 2000
Export Citation:
Assignee:
Cancer Research Ventures Limited
International Classes:
A61K31/428; A61K51/04; A61P35/00; C07D277/66; C07F7/22; (IPC1-7): C07D277/66; A61K31/428; A61P35/00
Other References:
JPN6011002155, ＡＮＡＬＹＴＩＣＡＬ ＳＣＩＥＮＣＥＳ, 1994, Ｖｏｌ．１０, ｐｐ．１７−２３
Attorney, Agent or Firm:
Minoru Senda (1 person outside)