Title:
【発明の名称】PPAR―γに対するアゴニスト活性を有する置換4―ヒドロキシフェニルアルカン酸誘導体
Document Type and Number:
Japanese Patent JP3255930
Kind Code:
B2
Abstract:
A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C1-6alkyl, C1-3alkoxy, C1-3fluoroalkoxy, nitrile, or -NR7R8 where R7 and R8 are independently hydrogen or C1-3alkyl; (ii) a 5- or 6-membered hetrocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur; and (iii) a fused bicyclic ring (a), wherein ring C represents a heterocyclic group as defined in point (ii) above, which bicyclic ring is attached to group B via a ring atom of ring C; B is selected from the group consisting of: (iv) C1-6alkylene; (v) -MC1-6alkylene or C1-6alkyleneMC1-6alkylene, wherein M is O, S, or -NR2 wherein R2 represents hydrogen or C1-3alkyl; (vi) a 5- or 6-membered heterocyclic group containing at least one nitrogen heteroatom and optionally at least one further heteroatom selected from oxygen, nitrogen and sulfur and optionally substituted by C1-3alkyl; and (vii) Het-C1-6alkylene, wherein Het represents a heterocyclic group as defined in point (vi) above; Alk represents C1-3alkylene; R1 represents hydrogen or C1-3alkyl; Z is selected from the group consisting of: (viii) -(C1-3alkylene) phenyl, which phenyl is optionally substituted by one or more halogen atoms; and (ix) -NR3R4, wherein R3 represents hydrogen or C1-3alkyl, and R4 represents -Y-(C=O)-T-R5, or -Y-(CH(OH))-T-R5.
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Inventors:
Timothy, Mark, Wilson
Robert, anthony, moke, junior
Istvan, Kaldor
Brad, Richard, Genk
David, Norman, Deaton
John, Lauren, Collins
Jeffrey, Edmond, Cove
Marcus, Brackeen
Matthew, Jude, Sharp
John, Mark, Ocho Lagan
Greg, Alan, Ericsson
Gladi, Evan, Boswell
Robert, anthony, moke, junior
Istvan, Kaldor
Brad, Richard, Genk
David, Norman, Deaton
John, Lauren, Collins
Jeffrey, Edmond, Cove
Marcus, Brackeen
Matthew, Jude, Sharp
John, Mark, Ocho Lagan
Greg, Alan, Ericsson
Gladi, Evan, Boswell
Application Number:
JP53058697A
Publication Date:
February 12, 2002
Filing Date:
February 26, 1997
Export Citation:
Assignee:
GLAXO GROUP LTD.
International Classes:
A61K31/00; A61K31/192; A61K31/195; A61K31/215; A61K31/216; A61K31/353; A61K31/38; A61K31/381; A61K31/40; A61K31/415; A61K31/4164; A61K31/4184; A61K31/42; A61K31/421; A61K31/422; A61K31/423; A61K31/425; A61K31/426; A61K31/427; A61K31/44; A61K31/4402; A61K31/4439; A61K31/445; A61K31/4453; A61K31/454; A61K31/495; A61K31/496; A61K31/535; C07D295/18; A61K31/5375; A61K31/5377; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; C07C229/36; C07C229/56; C07C235/30; C07C237/40; C07C255/54; C07C323/12; C07D207/08; C07D207/12; C07D213/64; C07D213/65; C07D213/70; C07D213/74; C07D231/12; C07D233/54; C07D233/64; C07D235/12; C07D237/14; C07D249/08; C07D261/08; C07D263/32; C07D263/56; C07D277/24; C07D277/42; C07D311/22; C07D333/36; C07D401/04; C07D405/04; C07D413/04; C07D413/12; C07D417/04; (IPC1-7): C07C229/36; A61K31/195; A61K31/215; A61K31/38; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/445; A61K31/495; A61K31/535; A61P3/06; A61P3/10; A61P9/04; A61P9/10; A61P9/12; C07C237/40; C07D207/12; C07D213/74; C07D233/64; C07D263/32; C07D263/56; C07D277/24; C07D295/18; C07D333/36; C07D413/04
Domestic Patent References:
| JP8325263A | ||||
| JP8325264A | ||||
| JP8225550A | ||||
| JP656663A | ||||
| JP656662A | ||||
| JP5155828A |
Other References:
【文献】国際公開94/22834(WO,A1)
Attorney, Agent or Firm:
Kazuo Sato (2 outside)