Title:
【発明の名称】置換アザ-オキシインドール誘導体
Document Type and Number:
Japanese Patent JP2003502280
Kind Code:
A
Abstract:
Compounds of formula (I) and methods for their use and manufacture. The compounds and compositions of the present invention are generally useful pharmacologically as therapeutic agents in disease states alleviated by the inhibition or antagonism of protein kinase activated signalling pathways in general, and in particular in the pathological processes which involve aberrant cellular proliferation, such disease states including tumor growth, restenosis, atherosclerosis, and thrombosis. In particular, the present invention relates to a series of substituted aza-oxindole compounds, which exhibit protein tyrosine kinase and protein serine/threonine kinase inhibition, and which are useful for the prevention of chemotherapy-induced alopecia.
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Inventors:
Philip, Anthony, Harris
Lee, Frederick, Kuiper
Karen, Elizabeth, Lucky
James, Marvin, Beer
Lee, Frederick, Kuiper
Karen, Elizabeth, Lucky
James, Marvin, Beer
Application Number:
JP2000605588A
Publication Date:
January 21, 2003
Filing Date:
March 03, 2000
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K31/437; A61K31/4709; A61P1/16; A61P3/10; A61P7/00; A61P7/04; A61P9/10; A61P9/14; A61P13/12; A61P17/06; A61P17/14; A61P17/16; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06; A61P43/00; C07D471/04; C07D471/14; C07D513/04; C07D513/14; C07B61/00; (IPC1-7): C07D471/04; A61K31/437; A61K31/4709; A61P1/16; A61P3/10; A61P7/00; A61P7/04; A61P9/10; A61P9/14; A61P13/12; A61P17/06; A61P17/14; A61P17/16; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06; A61P43/00
Attorney, Agent or Firm:
Kenji Yoshitake (3 others)