Title:
【発明の名称】細胞増殖阻害のための置換ビスインドリルマレイミド
Document Type and Number:
Japanese Patent JP2000516588
Kind Code:
A
Abstract:
Compounds of the formulawhereinR1 and R1' are independently alkyl, aryl, alkenyl or alkynyl;R2 and R2' are independently hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl, haloalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acylaminoalkyl, alkylsulphonylaminoalkyl, arylsulphonyl-aminoalkyl, mercaptoalkyl, alkylthioalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, alkylthio or alkylsulphinyl;R4, R5, R6, R7, R4', R5', R6', and R7' each independently are hydrogen,CO2R9, CH2OR10, CHO, CH2NR11R12, CON(R13)2, halogen, cyano, aryl, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino, aralkyloxy, acylamino, monoalkylamino, dialkylamino, thio, alkyl, alkylsulphinyl, alkylsulphonyl, arylsulphinyl, azide, phosphate or phosphonate provided that at least one of R4, R5, R6 and R7 and at least one of R4', R5', R6', and R7' are other than hydrogen, with the proviso that when R6 is methoxy, R5 or R5' are not methoxy;R8 is alkyl or aryl;R9 is alkyl or aryl;R10 is hydrogen, alkyl or aryl;R11 and R12 are independently hydrogen, alkyl, aryl, aralkyl or acyl;R13 is hydrogen, alkyl, aryl or aralkyl; andone of X and Y signifies O and the other signifies O, S, (H,OH) or (H,H); as well as pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts of acidic compounds of formula I with bases and or basic compounds of formula I with acids are antiproliferative agents useful in the treatment of cancer.
Inventors:
Dingla, Urvashi Hoda
Flynn, Donna Mary
Keith, Dennis Dalton
Flynn, Donna Mary
Keith, Dennis Dalton
Application Number:
JP50845298A
Publication Date:
December 12, 2000
Filing Date:
July 19, 1997
Export Citation:
Assignee:
Ef Hoffman-La Roche Age
International Classes:
A61K31/40; A61K31/404; A61P35/00; C07D403/14; (IPC1-7): C07D403/14; A61K31/404; A61P35/00
Attorney, Agent or Firm:
Hajime Tsukuni (2 outside)