Title:
【発明の名称】置換ピロリジンヒドロキサメートメタロプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2002511448
Kind Code:
A
Abstract:
The invention provides compounds which are potent inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to compounds having a structure according to the following Formula (I):wherein R1, R2, X, Z, m, and n are defined below.to This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of diseases and conditions which are characterized by unwanted metalloprotease activity. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for metalloprotease-related maladies using these compounds or the pharmaceutical compositions containing them.
Inventors:
Chiang Menyang
Natchas Michael George
Devis Wanash
Almstead Neil Gregory
Thai Wye Tsunde Orabishi
Pickle Stanislaw
Natchas Michael George
Devis Wanash
Almstead Neil Gregory
Thai Wye Tsunde Orabishi
Pickle Stanislaw
Application Number:
JP2000543431A
Publication Date:
April 16, 2002
Filing Date:
April 09, 1999
Export Citation:
Assignee:
THE PROCTER & GAMBLE COMPANY
International Classes:
A61K31/40; A61K31/4025; A61K31/4155; A61K31/42; A61K31/433; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/454; A61K31/496; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61P1/02; A61P9/00; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D207/48; C07D401/12; C07D403/12; C07D405/04; C07D409/04; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; (IPC1-7): C07D207/48; A61K31/40; A61K31/4025; A61K31/4155; A61K31/42; A61K31/433; A61K31/4439; A61K31/454; A61K31/496; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61P1/02; A61P9/00; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D401/12; C07D403/12; C07D405/04; C07D409/04; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12
Attorney, Agent or Firm:
Yoshikazu Tani (2 outside)
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