【発明の名称】5-HT7受容体アンタゴニストとしてのスルホンアミド誘導体 - SmithKline Beecham Public Limited Company

Title:

【発明の名称】5-HT7受容体アンタゴニストとしてのスルホンアミド誘導体

Document Type and Number:

Japanese Patent JP2002540099

Kind Code:

A

Abstract:

The invention relates to novel sulfonamide compounds having 5-HT7 receptor antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.wherein:Q is phenyl or thienyl;R<1 >is halogen, hydroxy, C1-6alkyl, CF3, OCF3 or C1-6alkoxy;m is 0, 1, 2 or 3;R<2 >is C1-4alkyl;X is carbon or CH, is a single bond when X is nitrogen or CH or is a double bond when X is carbon,D is a single bond, C=O, O or CH2 subject to the proviso that when X is nitrogen then D is not oxygen;P is a 5 or 6 membered heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a benzofused heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur;R<3 >is C1-6alkyl optionally substituted by NR<4>R<5>, aryl, arylC1-6alkyl, C1 6alkoxy, C1-6alkylthio, cyano, hydroxy, nitro, halogen, CF3, C2F5, NR<4>R<5>, CONR<4>R<5>, NR<4>COR<5>, S(O)pNR<4>R<5>, CHO, OCF3, SCF3, CH2OR<6>, CO2R<6 >or COR<6 >where p is 0, 1 or 2 and R<4>, R<5 >and R<6 >are independently hydrogen, C1-6alkyl, aryl or arylC1-6alkyl;n is 0, 1, 2 or 3.

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Inventors:

Peter John Label

Application Number:

JP2000606574A

Publication Date:

November 26, 2002

Filing Date:

March 14, 2000

Export Citation:

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Assignee:

SmithKline Beecham Public Limited Company

International Classes:

C07D295/12; A61K31/445; A61K31/451; A61K31/454; A61K31/495; A61K31/496; A61K31/505; A61P1/04; A61P9/00; A61P13/12; A61P25/00; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P29/00; A61P43/00; C07D211/14; C07D211/30; C07D211/32; C07D211/46; C07D215/46; C07D235/30; C07D239/42; C07D263/58; C07D277/82; C07D295/13; C07D401/04; C07D409/12; C07D413/04; C07D417/04; (IPC1-7): C07D211/14; A61K31/445; A61K31/451; A61K31/454; A61K31/495; A61K31/496; A61K31/505; A61P1/04; A61P9/00; A61P13/12; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P29/00; A61P43/00; C07D211/32; C07D211/46; C07D215/46; C07D235/30; C07D239/42; C07D263/58; C07D277/82; C07D295/12; C07D401/04; C07D413/04; C07D417/04

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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