【発明の名称】合成インスリン模倣物質 - THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Title:

【発明の名称】合成インスリン模倣物質

Document Type and Number:

Japanese Patent JP2001512130

Kind Code:

A

Abstract:

Compounds are disclosed which have the formula (I) wherein R1-R2 are each independently selected from the group consisting of: (a) a hydrogen atom; and (b) a lower alkyl group, straight or branched chain, having 1 to 8 carbon atoms; or R1-R2 and the nitrogen atom to which they are bonded may together form a heterocyclic group; R3-R10 are each independently selected from the group consisting of: (a) a hydrogen atom; (b) an alkyl group, straight or branched chain, having 1 to 24 carbon atoms; (c) a cycloalkyl group having 3 to 10 carbon atoms; (d) an alkenyl group, straight or branched chain, having 2 to 24 carbon atoms; (e) a cycloalkenyl group having 4 to 10 carbon atoms and one or more non-adjacent double bonds; (f) an aryl group having 6 to 10 carbon atoms; (g) an aralkyl group having 7 to 34 carbons atoms; (h) a heteroaryl group having 4 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen, nitrogen and sulfur; (i) a carboxyalkyl group, straight or branched chain, having 2 to 24 carbon atoms; (j) a carboxyaryl group having 7 to 34 carbon atoms; and (k) a heterocyclic group having 2 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen; or any adjacent two of R3-R10may together form a cycloalkyl group or heterocyclic group; and X1 and X2 are each independently selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom. Pharmaceutical compositions containing these compounds and the use thereof for the treatment of disorders of glucose metabolism are also disclosed.

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Inventors:

Learner, Joseph
Price, john
Picariero, thomas
Fan, roller

Application Number:

JP2000505177A

Publication Date:

August 21, 2001

Filing Date:

July 29, 1998

Export Citation:

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Assignee:

THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION

International Classes:

C07H15/04; A61K31/70; A61K31/7028; A61K31/7034; A61P3/08; A61P3/10; C07H15/207; C07H17/04; (IPC1-7): C07H15/207; A61K31/7034; A61P3/10

Attorney, Agent or Firm:

Shusaku Yamamoto

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