Title:
【発明の名称】合成ペプチドおよび自己免疫疾患治療のための使用方法
Document Type and Number:
Japanese Patent JP2003521448
Kind Code:
A
Abstract:
The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides or peptides to the mammal.
Inventors:
Stromminger, Jack El
Fridkiss-Harelli, Masha
Fridkiss-Harelli, Masha
Application Number:
JP2000561205A
Publication Date:
July 15, 2003
Filing Date:
July 22, 1999
Export Citation:
Assignee:
The President and Fellows of Harvard College
International Classes:
C12P21/02; A61K38/00; A61K38/08; A61K38/16; A61K39/00; A61L27/22; A61P1/00; A61P3/10; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P37/06; C07K2/00; C07K4/00; C07K5/11; C07K7/06; C07K7/08; C07K14/00; C07K14/74; C07K; (IPC1-7): C07K14/74; A61K38/00; A61P1/00; A61P3/10; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P37/06; C07K2/00; C07K4/00; C07K7/08; C12P21/02
Attorney, Agent or Firm:
Yuzo Yamazaki (3 others)