Title:
【発明の名称】FLINTポリペプチドの治療用への適用
Document Type and Number:
Japanese Patent JP2003520761
Kind Code:
A
Abstract:
Mature FLINT protein (mFLINT) binds FasL and LIGHT, and prevents FasL-Fas interaction. mFLINT inhibits FasL-Fas-mediated apoptotic and proinflammatory activity, and is useful in treating disorders that may be associated with abnormal apoptosis and inflammation. The invention provides the amino acid and nucleotide sequences of FLINT and mature FLINT. Therapeutic compositions and methods of treatment utilizing mFLINT also are provided.
Inventors:
Fredrick Jay Cohen
James Arthur Posada
Daniel Wiada
James Arthur Posada
Daniel Wiada
Application Number:
JP2000589204A
Publication Date:
July 08, 2003
Filing Date:
December 21, 1999
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
C12N15/09; A61K38/00; A61P1/04; A61P9/10; A61P11/00; A61P19/10; A61P35/00; A61P37/02; C07K14/705; A61K35/00; (IPC1-7): A61K38/00; A61P1/04; A61P9/10; A61P11/00; A61P19/10; A61P35/00; A61P37/02
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)