Title:
【発明の名称】組織プラスミノ―ゲン活性化因子置換変異体
Document Type and Number:
Japanese Patent JP2532193
Kind Code:
B2
Abstract:
Biologically active tissue plasminogen activator (t-PA) variants with greatly increased clot lysis activity as compared to wild-type t-PA are prepared, wherein the arginine residue at position 299 is replaced by an aspartic acid residue. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences and host cells transformed with the expression vectors. The variants may be used in pharmaceutical preparations to treat a vascular disease or condition, or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Inventors:
Bennett, William F. The Third
Application Number:
JP50335492A
Publication Date:
September 11, 1996
Filing Date:
December 16, 1991
Export Citation:
Assignee:
Genentech, Inc.
International Classes:
A61P7/02; C07K14/00; C07K14/745; C12N5/10; C12N9/64; C12N9/72; C12N15/09; C12N15/58; A61K38/46; C12P21/02; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; C12N9/64; C12N5/10; C07K14/745; A61K38/46
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)
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