【発明の名称】トランス-スプライシングリボザイム

Title:

【発明の名称】トランス-スプライシングリボザイム

Document Type and Number:

Japanese Patent JPH06504444

Kind Code:

A

Abstract:

The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. Inactive pro-ribozyme forms are also described.

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Inventors:

Goodman, Howard M
Briles, David, Yi.

Application Number:

JP50454092A

Publication Date:

May 26, 1994

Filing Date:

January 16, 1992

Export Citation:

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Assignee:

The General Hospital Corporation

International Classes:

C07K7/06; C07K14/34; C12N9/12; C07K14/00; C12N15/09; C12N15/113; C12N15/52; C12N15/66; C12N15/72; C12N15/82; C12N15/90; A61K38/00; C12N; (IPC1-7): C12N15/52; C07K7/06; C07K13/00; C12N9/12

Attorney, Agent or Firm:

Aoyama Ryo (1 person outside)

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