Title:
【発明の名称】アテローム硬化症及び他の心・血管疾患及び炎症性疾患のための治療
Document Type and Number:
Japanese Patent JP3120091
Kind Code:
B2
Abstract:
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
Inventors:
Medford, Russell, M
Alexander, arel, wayne
Parsa Salasse, Sampass
Can, bobby, vie
Offerman, Margaret, Kay
Alexander, arel, wayne
Parsa Salasse, Sampass
Can, bobby, vie
Offerman, Margaret, Kay
Application Number:
JP52920095A
Publication Date:
December 25, 2000
Filing Date:
May 10, 1995
Export Citation:
Assignee:
Emory, University
International Classes:
G01N33/50; A61K31/10; A61K31/105; A61K31/145; A61K31/185; A61K31/198; A61K31/26; A61K31/27; A61K31/28; A61K31/325; A61K31/365; A61K31/40; A61K31/455; A61K31/55; A61K38/00; A61K45/00; A61K45/06; A61K49/00; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P17/00; A61P29/00; A61P35/00; A61P43/00; C07C333/04; C07C333/08; C07C333/16; C07D295/21; G01N33/15; G01N33/68; G01N33/92; (IPC1-7): A61K45/00; A61K31/27; A61P9/00; A61P9/10; A61P29/00; A61P43/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Michio Akaoka (1 person outside)