Title:
【発明の名称】アンドロゲン過剰症の治療
Document Type and Number:
Japanese Patent JPH10511958
Kind Code:
A
Abstract:
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5 alpha -reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5 alpha -reductase enzyme, NADPH. Until the present invention, it was not known or predicted that 3-oxo-4-azasteroids having a 1,2-double bond would form a complex with NADPH by the mechanism of 5 alpha -reductase in vivo. The invention further relates to the novel inhibitor-cofactor complex and pharmaceutical compositions containing the complex.
Inventors:
Bull, Herb Gee
Harris, The Georgia S
Harris, The Georgia S
Application Number:
JP52128996A
Publication Date:
November 17, 1998
Filing Date:
January 02, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
C07J41/00; A61K31/58; A61K47/48; C07J73/00; (IPC1-7): C07J41/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)