Title:
【発明の名称】スタフィロコッカス・アウレウス由来の2成分シグナルトランスダクションシステムタンパク質
Document Type and Number:
Japanese Patent JPH11506018
Kind Code:
A
Abstract:
Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
Inventors:
Wallis, Nikola
Hodgson, John Edward
Hodgson, John Edward
Application Number:
JP52342597A
Publication Date:
June 02, 1999
Filing Date:
December 20, 1996
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
C12N15/09; A61K31/70; A61K31/7088; A61K38/00; A61K39/07; A61K39/085; A61K45/00; A61K48/00; A61P31/04; C07K14/195; C07K14/31; C07K16/12; C12N1/15; C12N1/19; C12N1/20; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/68; A61K39/00; (IPC1-7): C12N15/09; C12P21/02; C12N1/21; C07K16/12; C07K14/31; A61K48/00; A61K45/00; A61K38/00; A61K31/70
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)