Title:
【発明の名称】インフルエンザ菌用ワクチンおよび診断法
Document Type and Number:
Japanese Patent JP3066339
Kind Code:
B2
Abstract:
Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of PBOMP-1 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passage immunization. Use of the nucleotide sequences encoding the PBOMP related peptides and proteins in hybridization assays is also described.
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Inventors:
Deichi, Robert A
Gyrotonic, Gully
Green, blues
Gyrotonic, Gully
Green, blues
Application Number:
JP10186597A
Publication Date:
July 17, 2000
Filing Date:
April 18, 1997
Export Citation:
Assignee:
American Cyanamid Company
International Classes:
G02F1/35; A61K31/00; A61K38/00; A61K39/00; A61K39/102; A61K39/145; A61K39/395; A61K39/42; A61P31/00; A61P31/04; C07H21/04; C07K14/00; C07K14/005; C07K14/11; C07K14/195; C07K14/285; C07K16/00; C07K16/12; C12N1/20; C12N1/21; C12N15/00; C12N15/09; C12N15/62; C12N15/70; C12P21/02; C12Q1/68; G01N33/50; G01N33/569; G01N33/577; H01S3/08; H01S3/082; H01S3/098; H01S3/106; H01S3/16; H01S5/065; H01S5/14; C12R1/19; C12R1/91; C12R1/92; (IPC1-7): C12N15/09; C12N1/21
Attorney, Agent or Firm:
Yuusuke Hiraki