Title:
【発明の名称】ビタミンD類似体
Document Type and Number:
Japanese Patent JPH09500637
Kind Code:
A
Abstract:
The present invention relates to novel 1 alpha -hydroxy vitamin D derivatives in which the 17-position side chain carries an azide or optionally substituted 1,2,3-triazole group, including compounds of general formula (I) where R1 represents a methyl group having alpha - or beta -configuration; W represents a valence bond or a C1-5 alkylene group; X represents azide or an optionally substituted triazole group; and A= represents a cyclohexylidene moiety characteristic of the A-ring of a 1 alpha -hydroxylated vitamin D or analogue thereof. Active compounds of the invention exhibit cell modulating activity while exhibiting a substantial lack of calcaemic effect.
Inventors:
Hets, robert henry
Larm Gopal, Marathi
Let's Day, Gatsdam Sutuba
Setay, Sundara, Katogum, Srinivasa Setay
Larm Gopal, Marathi
Let's Day, Gatsdam Sutuba
Setay, Sundara, Katogum, Srinivasa Setay
Application Number:
JP50502195A
Publication Date:
January 21, 1997
Filing Date:
July 22, 1994
Export Citation:
Assignee:
Research institute for far medicine and chemistry incorporated
International Classes:
A61K31/41; A61K31/445; A61K31/535; A61P9/12; A61P11/00; A61P17/00; A61P25/28; A61P29/00; A61P35/02; A61P37/00; A61P37/06; C07C401/00; C07D249/04; (IPC1-7): C07D249/04; A61K31/41; A61K31/445; A61K31/535; C07C401/00
Attorney, Agent or Firm:
Chika Takagi (2 outside)