PURPOSE: To raise permeability and percutaneous absorption of physiological activator, by using a multi-component carrier system consisting of at least one adjuvant (component A) and at least one solvent (component B).
CONSTITUTION: The component A of at least one (10W26C aliphatic monoalcohol and its mixture) is blended with the component B of at least one [thioglycerol, lactic acid or its ester, cyclic urea, compound shown by the formula I (R1-4 are H, 1W4C lower alkyl, or 1W2C acyl), compound shown by the formula II (R5 is H, or 1W4C lower alkyl; n is 3W5), compound shown by the formula III (R6 is H, 1W3C alkyl; R7 and R8 are 1W3C alkyl; with the proviso that total number of carbons of R6, R7, and R8 is at least ≥3], the blend is mixed with a physiological activator, and applied to the skin. An amount of the component A to be used is 0.1W80wt% based on total amounts of the components A and B. Benzodiazepine, etc. may be cited as the activator, and its amount is 0.01W50wt% based on the total amounts.
UIRUFURETSUDO EE SUKINAA
JIYOOJI HERAA
| JPS5132724A | 1976-03-19 |
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