Title:
【発明の名称】水溶性カンプトテシン誘導体
Document Type and Number:
Japanese Patent JPH08503221
Kind Code:
A
Abstract:
The present invention relates to water soluble, camptothecin derivatives of formula (I). wherein A represents a moiety of the formula (IIA), (IIB) or (IIC): X is selected from the group consisting of alkyl, aryl, (CH2)mOR1, (CH2)mSR1 and (CH2)mNR1R2 wherein m is an integer of 0 to 6, and R1 and R2 are hydrogen, lower alkyl, aryl or together with the nitrogen form a 5-7 membered ring; q is an integer of 0 to 2; n represents the integer 1 or 2; p is an integer of 1 to 6; Y and W are selected from the group consisting of alkyl, aryl, alkoxy, aryloxy and amino, Q is oxygen or sulfur; P is phosphorus; J represents the atoms necessary to complete a 5 or 6 membered aromatic ring; and the pharmaceutically acceptable salts thereof; their use as topoisomerase inhibitors, their preparation; and their use in the treatment of cancer.
Inventors:
Besterman, jeffrey mark
Evans, Michael Glen
Lucky, Karen Elizabeth
Lucio, Michael Joseph
Peel, Michael Robert
Sternback, daniel david
Evans, Michael Glen
Lucky, Karen Elizabeth
Lucio, Michael Joseph
Peel, Michael Robert
Sternback, daniel david
Application Number:
JP51239894A
Publication Date:
April 09, 1996
Filing Date:
November 10, 1993
Export Citation:
Assignee:
Glaxo, Inc.
International Classes:
A61K31/47; A61K31/675; A61P35/00; A61P43/00; C07D317/66; C07D319/18; C07D491/22; C07F9/6561; (IPC1-7): C07D491/22; A61K31/47; A61K31/675; C07D317/66; C07D319/18; C07F9/6561
Attorney, Agent or Firm:
Kazuo Sato (2 outside)