Title:
【発明の名称】外胚葉誘導組織における腫瘍増殖を阻害する活性物質及び組成物
Document Type and Number:
Japanese Patent JP2001518091
Kind Code:
A
Abstract:
The invention relates to an active substance inhibiting tumorous proliferation in ectoderm derived tissues and to a composition containing such substance. A process for producing the above active substance comprises the following steps:fertilized ovum of human beings or sea water fishes or fresh water fishes is subjected to cell wall destruction preferably 24 hours, more preferably 14-16 hours after fertilization, then the material is ultracentrifuged, the supernatant is separated, the sediment is homogenized, then ultracentrifuged several times, and each time the supernatant and the sediment are separated, thereafter all supernatant fractions are combined and centrifuged preferably at 8,000-15,000 rpm, the supernatant obtained is separated and diluted preferably with physiological solution, preferably in 1:2 ratio by weight, then the active substance is separated from contaminants, preferably the obtained material is subjected to a series of gel filtration at least twice, then the filtered substance is lyophilized.
Inventors:
Mugbasi, Jura
Application Number:
JP54132398A
Publication Date:
October 09, 2001
Filing Date:
March 24, 1998
Export Citation:
Assignee:
Mugbasi, Jura
International Classes:
A61K35/54; A61K35/56; A61K38/17; A61P35/00; C07K1/34; C07K14/46; A61K35/60; A61K38/00; (IPC1-7): A61K35/60; A61K35/54; A61K35/56; A61P35/00; C07K1/34; C07K14/46
Attorney, Agent or Firm:
Takashi Ishida (4 others)