Title:
【発明の名称】抗生物性化合物
Document Type and Number:
Japanese Patent JP3313366
Kind Code:
B2
Abstract:
PCT No. PCT/GB93/00603 Sec. 371 Date Nov. 26, 1993 Sec. 102(e) Date Nov. 26, 1993 PCT Filed Mar. 24, 1993 PCT Pub. No. WO93/19070 PCT Pub. Date Sep. 30, 1993.The present invention relates to carbapenems and provides a compound of the formula (I) (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; and the thienyl ring is optionally further substitued by one or two substituents selected from halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, trifluoromethyl, C1-4alkoxycarbonyl, amino, C1-4alkylamino, di-C1-4alkylamino, sulfonic acid, C1-4alkylS(O)n- (wherein n is 0-2), C1-4alkanoylamino, C1-4alkanoyl(N-C1-4alkyl)amino, carbamoyl, C1-4alkylcarbamoyl, di-C1-4alkylcarbamoyl and N-C1-4alkanesulfonamido; or by a tetramethylene group attached to adjacent carbon atoms on the thienyl ring; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.
Inventors:
Jung, Frederik Henri
Application Number:
JP51639893A
Publication Date:
August 12, 2002
Filing Date:
March 24, 1993
Export Citation:
Assignee:
Geneca Limited
Zeneca-Pharma Societe Anonym
Zeneca-Pharma Societe Anonym
International Classes:
A61K31/397; A61K31/4025; A61P31/04; C07D409/12; C07D409/14; A61K31/40; C07D477/00; C07D477/20; C07F9/568; (IPC1-7): C07D477/00; A61K31/40; A61P31/04; C07D409/12; C07D409/14
Attorney, Agent or Firm:
Toshio Yano (2 outside)