Title:
【発明の名称】トリコテセン結合体を含む抗腫瘍剤
Document Type and Number:
Japanese Patent JPH072651
Kind Code:
B2
Abstract:
Conjugates of trichothecenes and agents that bind to a defined population of cells are disclosed. Preferred are conjugates of trichothecene molecules with polyolonal or monoclonal antibodies or fragments thereof that recognize antigens that are present only on tumor cells or are augmented in their expression on tumor cells as compared to normal tissues. Trichothecene molecules are coupled to the agent through non-covalent and covalent linkages, such as peptide bonds, disulfide bonds, thioester bonds, or thioether bonds. A method for inhibiting the growth and metabolism of antigen- positive cells is also disclosed.
Inventors:
GAUSARA PABANASASHIBAMU
Application Number:
JP24561786A
Publication Date:
January 18, 1995
Filing Date:
October 17, 1986
Export Citation:
Assignee:
NEORX CORP
International Classes:
A61K31/335; A61K31/35; A61K31/357; A61K31/365; C12N15/02; A61K39/395; A61K47/00; A61K47/48; A61P35/00; C07D321/00; C07D493/10; C07D493/20; C07D493/22; C07K1/113; C07K14/00; C07K16/00; C12N15/00; C12P17/06; C12P21/00; C12P21/08; G01N33/532; (IPC1-7): A61K39/395; A61K31/335; A61K31/35; A61K39/395
Domestic Patent References:
| JP57193480A | ||||
| JP5843926A | ||||
| JP57179124A | ||||
| JP5748924A | ||||
| JP4641905B1 | ||||
| JP454504B1 |
Attorney, Agent or Firm:
Aoki Ao (5 people outside)
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