Title:
【発明の名称】生物活性巨大分子を含む水性エアゾール製剤及び該エアゾールの製造方法
Document Type and Number:
Japanese Patent JP2001513492
Kind Code:
A
Abstract:
Preparation of aerosols for inhalative application of biologically active macromolecules (I) (especially peptides), from an aerosol preparation which contains (I), comprises: (a) measuring a dosage amount of (I) in a measuring chamber in a nebuliser which is free of propellant gases; and (b) spraying (I) to inhalable droplets (with a particle size less than 10 mu m) within 1-2 seconds. Spraying is carried out at a pressure of 100-500 bar through a nozzle with a hydraulic diameter of 1-12 mu m. Also claimed is an aqueous aerosol composition for inhalative administration of (I), which contains 3-100 mg of (I) per ml.
Inventors:
Ramche Herbert
Mead Christopher John Montague
Zielenberg Bernd
Limeholtz Ralph Christian
Mead Christopher John Montague
Zielenberg Bernd
Limeholtz Ralph Christian
Application Number:
JP2000506934A
Publication Date:
September 04, 2001
Filing Date:
July 31, 1998
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Comandito Gezelshaft
International Classes:
A61K9/00; A61K9/12; A61K31/7088; A61K38/04; A61K38/17; A61K38/20; A61K38/21; A61K38/22; A61K38/23; A61K38/28; A61K9/06; A61K38/29; A61K38/44; A61K38/45; A61K38/46; A61K39/00; A61L9/12; A61M15/00; (IPC1-7): A61K9/06; A61K31/7088; A61K38/22; A61K38/28; A61K38/23; A61K38/04; A61K38/45; A61K38/46; A61K39/00; A61M15/00
Attorney, Agent or Firm:
Minoru Nakamura (9 outside)