Title:
【発明の名称】ポリ脂環式ホスホエステル化合物よりなる生分解性組成物、物品、及びその使用方法
Document Type and Number:
Japanese Patent JP2002500640
Kind Code:
A
Abstract:
Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I:wherein:each of R and R' is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents;L is a divalent cycloaliphatic group;R'' is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; andn is 5 to 1,000,wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R' or R'' is a biologically active substance.Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.
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Inventors:
Wenbin Dang
Hi-Kuan Mao
Irina Sipanova Kadiyara
Come W. Leong
Tsong Tuao
James P English
Hi-Kuan Mao
Irina Sipanova Kadiyara
Come W. Leong
Tsong Tuao
James P English
Application Number:
JP54746098A
Publication Date:
January 08, 2002
Filing Date:
April 30, 1998
Export Citation:
Assignee:
Guildford Pharmaceuticals Inc.
Johns Hopkins University School of Medicine
Johns Hopkins University School of Medicine
International Classes:
A61K47/34; A61K47/48; A61L27/00; A61L27/18; A61L31/06; C08G79/04; C08K5/00; A61K47/30; C08L85/02; (IPC1-7): A61K47/30; A61K47/48; A61L27/00; C08K5/00; C08L85/02
Attorney, Agent or Firm:
Masahiro Tanaka