Title:
【発明の名称】ヒトフォン・ヴィレブランド因子のアミノ酸配列を含むポリペプチドをコードするcDNA、及び該cDNAを含有する宿主細胞
Document Type and Number:
Japanese Patent JP3123650
Kind Code:
B2
Abstract:
Full length human von Willebrand factor (vWF) cDNA was assembled from partial, overlapping vWF cDNAs. This cDNA construct includes an "open" reading frame of 2,813 amino-acid residues, apparently representing a (pre)-pro-sequence of 763 and mature vWF of 2,050 amino acids. Both the pro- sequence and mature vWF harbor an arg-gly-asp ("R-G-D") sequence which has been implicated in cell attachment functions. It is assumed that the pro-sequence is equivalent to von Willebrand Antigen II (vW AgII). The (glyco)-proteins prepared by cultivation of microorganisms or other hosts like animal or human cells containing a plasmide or phage with said cDNA-coding may be used in pharmaceutical compositions intended for administration to patients with the von Willebrand's disease.
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Inventors:
Panna Cook Hans
Full Veer Colonelius Lambartz
Diahalda paul johan
Hearts Margareta Hendrika Luisa
Full Veer Colonelius Lambartz
Diahalda paul johan
Hearts Margareta Hendrika Luisa
Application Number:
JP7540886A
Publication Date:
January 15, 2001
Filing Date:
April 01, 1986
Export Citation:
Assignee:
Immuno age
International Classes:
A61K35/12; A61K35/14; A61K35/16; A61K38/16; C12N15/09; C07K14/745; C07K14/755; C07K17/10; C12N1/20; C12N5/10; C12N15/00; C12P21/00; C12P21/02; (IPC1-7): C12N15/09; C07K14/745; C12N1/21; C12P21/02
Other References:
FEDERATION PROCEEDING=1985
JOURNAL OF CELL BIOLOGY=1984
NUCLEIC ACIDS RESEARCH=1985
PROC.NATL.ACAD.SCI.=1985US
PROC.NATL.ACAD.SCI=1985US
THROMBOSIS RESEARCH=1984
JOURNAL OF CELL BIOLOGY=1984
NUCLEIC ACIDS RESEARCH=1985
PROC.NATL.ACAD.SCI.=1985US
PROC.NATL.ACAD.SCI=1985US
THROMBOSIS RESEARCH=1984
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)