Title:
【発明の名称】前立腺癌の治療に有効なコンジュゲート
Document Type and Number:
Japanese Patent JP2000509407
Kind Code:
A
Abstract:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH). 00000
Inventors:
Gullsky, Victor M
Fuen, Don-Mei
Dehuge Jones, Deborah
Fuen, Don-Mei
Dehuge Jones, Deborah
Application Number:
JP52059398A
Publication Date:
July 25, 2000
Filing Date:
October 27, 1997
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/337; A61K31/407; A61K31/475; A61K31/513; A61K31/517; A61K31/675; A61K31/704; A61K31/7048; A61K31/7064; A61K38/00; A61K47/48; A61P13/08; A61P35/00; C07K7/06; C07K7/08; C07K14/47; (IPC1-7): A61K47/48; C07K7/06; A61P35/00; A61P13/08; A61K38/00; A61K31/7064; A61K31/7048; A61K31/704; A61K31/675; A61K31/517; A61K31/513; A61K31/475; A61K31/407; A61K31/337
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)