【発明の名称】老人性痴呆症治療用組成物及びその治療方法

Title:

【発明の名称】老人性痴呆症治療用組成物及びその治療方法

Document Type and Number:

Japanese Patent JPH04504414

Kind Code:

A

Abstract:

PCT No. PCT/US90/00121 Sec. 371 Date Sep. 13, 1991 Sec. 102(e) Date Sep. 13, 1991 PCT Filed Jan. 12, 1990 PCT Pub. No. WO90/08315 PCT Pub. Date Jul. 26, 1990.Ginsenosides Rb1 and Rg1 enhance the availability of acetylcholine in the cortical and hippocampal regions of the brain and alleviaate the symptoms of Alzheimer-type senile dementia. The Rb1 or Rg1 may be administered together with a metabolic precursor for acetylcholine and/or with a cholinesterase inhibitor. Pure Rb1 is located from a mixture of ginsenosides by a process involving vacuum chromatography on silica gel. Preferably, the mixture of ginsenosides is enriched in Rb1 by partition between an aqueous system and water ethyl acetatebutanol.

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Inventors:

Pang Peter Katee
Wang Lawrence C H
Benisin Christiana Gee
Liu Fusing The Ray

Application Number:

JP50323890A

Publication Date:

August 06, 1992

Filing Date:

January 12, 1990

Export Citation:

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Assignee:

Pang Peter Katee
Wang Lawrence C H
Benisin Christiana Gee
Liu Fusing The Ray

International Classes:

A61K31/44; A61K31/66; A61K31/685; A61K31/704; A61K31/715; A61K36/00; A61K36/25; A61K45/06; A61K31/40; A61P21/00; A61P25/02; A61P25/28; A61P43/00; C07J17/00; (IPC1-7): A61K31/40; A61K31/44; A61K31/66; A61K31/685; A61K31/705; A61K35/78; A61K45/06; C07J17/00

Attorney, Agent or Firm:

Iwao Tamura

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